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Alcohol intoxication is a risk factor in some cases of catastrophic injury, in particular for unsupervised recreational activity.A study in the province of Ontario based on epidemiological data from 1986, 1989, 1992, and 1995 states that 79.2% of the 2,154 catastrophic injuries recorded for the study were preventable, of which 346 involved alcohol consumption.In addition to respiratory failure and accidents caused by effects on the central nervous system, alcohol causes significant metabolic derangements.Hypoglycaemia occurs due to ethanol's inhibition of gluconeogenesis, especially in children, and may cause lactic acidosis, ketoacidosis, and acute renal failure.Acetaldehyde is metabolised to acetate by acetaldehyde dehydrogenase (ALDH), which is found predominantly in liver mitochondria.
Ethanol is metabolised to acetaldehyde by alcohol dehydrogenase (ADH), which is found in many tissues, including the gastric mucosa.As drinking increases, people become sleepy, or fall into a stupor.After a very high level of consumption, the respiratory system becomes depressed and the person will stop breathing.Acute alcohol poisoning is a medical emergency due to the risk of death from respiratory depression or aspiration of vomit if vomiting occurs while the person is unresponsive.
Emergency treatment strives to stabilize and maintain an open airway and sufficient breathing, while waiting for the alcohol to metabolize.
This can be done by removal of any vomitus or, if the person is unconscious or has impaired gag reflex, intubation of the trachea.